Peptide half-life evidence reference
A half-life number is useful only with its measurement context. This reference covers selected examples that are commonly confused; it is not a dosing schedule or a complete pharmacokinetic database.
Key Takeaways
- Keep species, route and analyte with the value.
- Do not substitute hormone response duration for peptide elimination.
- Unknown human values remain unknown.
Selected research contexts
These entries deliberately preserve unresolved values instead of assigning them a convenient number.
| Compound / form | What the source supports | Limit |
|---|---|---|
| BPC-157 | Parent-compound half-life below 30 minutes in rat/dog IV and IM study conditions [1] | Not an established human subcutaneous value. |
| Long-acting CJC-1295 | Human study of prolonged GH and IGF-1 responses [2] | Hormone-response duration and peptide elimination are different measurements; do not transfer to no-DAC forms. |
| MOTS-c | Human endogenous measurements around exercise, alongside animal experiments [3] | No reliable administered human half-life established by this source. |
Read the label on every number
Record the molecule and modifications, species or participant population, administration route, measured analyte, sampling interval and model. A result for a metabolite or a radiolabel can answer a different question from a result for unchanged parent compound.
Half-life decay is a model, not a washout guarantee
In a simple first-order model, 50%, 25%, 12.5%, 6.25% and 3.125% remain after one to five half-lives. Five half-lives is not zero. Actual pharmacokinetics and downstream effects may differ; this arithmetic cannot define a safe interval or a time when effects must stop.
Why the chart does not prescribe a schedule
Dosing depends on indication, formulation, exposure, efficacy and safety evidence—not half-life alone. A source-free estimate should not become a treatment instruction through repetition.
Frequently Asked Questions
Is peptide half-life the same as vial shelf life?
No. Pharmacokinetic elimination describes what happens in a studied organism. Storage stability concerns a product under specified external conditions.
Can I calculate a dosing frequency from this chart?
No. The chart explains evidence and its limits; it does not establish a clinical regimen.