Melanotan II Dosing Protocol
Melanotan II (MT-2) is a synthetic melanocortin receptor agonist researched for skin pigmentation, with additional effects on appetite and libido observed in studies. Protocols use a loading phase to initiate pigmentation followed by maintenance.
Key Points
Step-by-Step Guide
Start with Low Test Dose
Begin with 0.25 mg subcutaneously to assess tolerance. Nausea and flushing are common initial reactions. If tolerated, proceed to loading dose.
Loading Phase
Increase to 0.5-1.0 mg daily for 2-4 weeks until desired pigmentation is achieved. Most users inject before bed to sleep through nausea.
Maintenance Phase
Once desired color is reached, reduce to 0.5 mg once or twice weekly with minimal UV exposure to maintain pigmentation.
UV Exposure
Brief UV exposure (10-20 minutes of natural sun or low-dose tanning bed) accelerates results. MT-2 enhances melanin production but UV triggers its distribution.
Monitor Skin
Watch for new or changing moles. Melanocortin activation affects melanocytes broadly. Annual dermatological screening is strongly recommended.
Warnings & Precautions
- !Not FDA-approved; significant safety concerns exist.
- !May promote growth of existing melanoma—contraindicated with skin cancer history.
- !Nausea is very common, especially at higher doses.
- !Monitor all moles for changes in size, shape, or color.
Frequently Asked Questions
How quickly does Melanotan II work?
Initial pigmentation changes appear within 1-2 weeks with UV exposure. Full results develop over 3-4 weeks of loading. Without UV exposure, results are significantly slower.
Is Melanotan II safe?
Safety data is limited. Concerns include mole darkening, potential melanoma risk in predisposed individuals, and cardiovascular effects from melanocortin receptor activation. It is not FDA-approved.
Does Melanotan II affect appetite?
Yes. Melanocortin receptors regulate appetite. Many users report appetite suppression as a secondary effect, which is consistent with the known biology of MC4R activation.