Semax Dosing Protocol
Semax is a synthetic ACTH(4-10) analog approved in Russia for cognitive impairment and stroke recovery. Available as a nasal spray, it offers a non-injection route for nootropic peptide research. Protocols derive from Russian clinical use and research community experience.
Key Points
Step-by-Step Guide
Select Concentration
Nasal spray typically comes in 0.1% (100 mcg/drop) or 1% (1000 mcg/drop). The 0.1% is standard for nootropic use; 1% is for clinical neurological conditions.
Determine Dose
Nootropic: 200-600 mcg/day (2-6 drops of 0.1%). Clinical: 600-1000 mcg/day. Start low and increase based on response.
Administer Nasally
Tilt head slightly back, apply drops inside nostril. Alternate nostrils. Avoid blowing nose for 10-15 minutes. Sniff gently to distribute.
Time Doses
Morning administration most common. Split doses (morning + early afternoon) avoid late-day stimulation affecting sleep. Avoid evening dosing.
Cycle Usage
3-4 weeks on, 1-2 weeks off. Some use 5 days on, 2 off. Cycling may prevent tolerance, though clinical evidence is limited.
Warnings & Precautions
- !Not FDA-approved in the US.
- !Evidence comes primarily from Russian studies.
- !Long-term neurotrophic effects not well characterized.
- !May interact with neurological medications.
Frequently Asked Questions
How quickly does Semax work?
Many users report cognitive effects within days—improved focus, verbal fluency, mental clarity. Full neurotrophic effects (BDNF upregulation) likely take weeks.
Is Semax addictive?
No. It does not directly affect dopamine reward pathways. Some notice decreased sharpness when discontinuing, which normalizes within days.
Can Semax be stacked with Selank?
Yes—a popular combination. Semax for nootropic effects (morning), Selank for anxiolytic effects (afternoon). They can be co-administered nasally.