Ipamorelin + CJC-1295 Stack Dosing Protocol
The Ipamorelin and CJC-1295 no-DAC combination is the gold standard GH peptide stack. Combining a ghrelin mimetic (GHRP) with a GHRH analog produces synergistic GH release that is both stronger and longer-lasting than either peptide alone.
Key Points
Step-by-Step Guide
Reconstitute Separately
Reconstitute each vial with bacteriostatic water independently. Keep in separate vials. Typical concentration: 100 mcg per 0.1 mL for each.
Dose Combination
Standard: 100-200 mcg Ipamorelin + 100 mcg CJC-1295 no DAC per injection. Can draw both into one syringe or use separate syringes.
Time Injections
Primary dose: 30-60 minutes before bed fasted. Optional: upon waking (fasted) and/or post-workout. 2-3 doses/day is typical.
Maintain Fasting Window
Fast 2-3 hours before and 30 minutes after each injection. Carbohydrates and insulin blunt GH release. Pre-bed fasted dose amplifies the nocturnal GH surge.
Cycle Protocol
Run 8-16 weeks, then 4-8 weeks off. Some use 5 days on, 2 off weekly. Monitor IGF-1 at baseline, 4 weeks, and end of cycle.
Monitor Side Effects
Watch for water retention, joint stiffness, tingling, blood sugar changes. Reduce dose if symptoms appear. Check fasting glucose periodically.
Warnings & Precautions
- !Neither peptide is FDA-approved.
- !GH elevation can worsen diabetes or active cancer.
- !Fasting protocol must be followed for efficacy.
- !Blood sugar monitoring recommended for pre-diabetic subjects.
Frequently Asked Questions
Why is the pre-bed dose most important?
The body produces its largest GH pulse during deep sleep. This stack amplifies that natural pulse, producing the highest GH levels during the primary repair window.
Can both be drawn into one syringe?
Yes—draw CJC-1295 first, then Ipamorelin. No evidence of interaction in the syringe, though some prefer separate injections for certainty.
What results to expect and when?
Improved sleep within 1-2 weeks, better recovery at 4-6 weeks, body composition changes at 8-12 weeks. IGF-1 elevation measurable within 2-4 weeks.