Ipamorelin Dosing Protocol
Ipamorelin is a selective growth hormone secretagogue stimulating GH release without significantly affecting cortisol or prolactin. Its selectivity makes it one of the most studied GHRP-class peptides, with timing relative to meals and sleep being critical for GH pulse amplification.
Key Points
Step-by-Step Guide
Establish Baseline
Obtain baseline IGF-1 and GH stimulation test results before initiating. This quantifies GH response to ipamorelin.
Set Standard Dose
The most researched dose is 200-300 mcg per injection subcutaneously. Start at 200 mcg and titrate to 300 mcg based on response.
Determine Frequency
Administer 1-3 times daily for GH pulse stimulation. Common schedules: morning, post-workout, and before bed. Pre-bed dosing is used in simpler protocols.
Time Around Meals
Inject fasted—at least 30 minutes before eating or 2 hours after. Elevated blood glucose and insulin blunt GH response.
Combine with GHRH
Ipamorelin is frequently paired with CJC-1295 no DAC at equimolar doses. The GHRP + GHRH combination produces synergistic GH release.
Assess Response
Measure IGF-1 at 4-week intervals. Monitor body composition, sleep quality, and recovery as secondary endpoints.
Warnings & Precautions
- !Ipamorelin is a research peptide not approved for clinical use.
- !Fasting state essential for optimal GH release.
- !Avoid in subjects with active malignancies due to GH proliferative effects.
- !Water retention and transient numbness may occur at higher doses.
Frequently Asked Questions
How much ipamorelin per injection?
Research protocols use 200-300 mcg. The 200 mcg dose provides reliable GH stimulation; 300 mcg is used for stronger pulses. Above 300 mcg shows diminishing returns.
When is the best time to administer ipamorelin?
Pre-bedtime fasted is most popular for single-dose protocols, amplifying the natural nocturnal GH pulse. For multi-dose: morning, post-workout, and pre-bed.
Why combine ipamorelin with CJC-1295?
They work through different mechanisms (GHRP + GHRH). Combined, they produce synergistic GH release 2-3x greater than either alone.