Tesamorelin Dosing Protocol
Tesamorelin is an FDA-approved synthetic GHRH analog (Egrifta) indicated for HIV-associated lipodystrophy. It stimulates pulsatile GH release more physiologically than exogenous GH, making it a unique option in the growth hormone peptide landscape.
Key Points
Step-by-Step Guide
Understand Approved Dosing
FDA-approved dose: 2 mg subcutaneously once daily. This is the only clinically validated dose from Phase 3 trials in HIV lipodystrophy patients.
Administration
Inject subcutaneously into the abdomen. Rotate injection sites. Administer at the same time daily, preferably in the evening to align with natural GH release patterns.
Reconstitution
Reconstitute the lyophilized powder with provided diluent. Roll vial gently—do not shake. Use within 24 hours of reconstitution if using sterile water, or per manufacturer instructions.
Monitor Efficacy
Track IGF-1 levels at baseline and 4-8 weeks. For lipodystrophy: measure trunk fat via DEXA scan. Monitor body composition changes over 26-week treatment periods.
Assess at 6 Months
Per FDA labeling, reassess at 6 months. If trunk fat has not decreased, consider discontinuation. Continued benefit requires ongoing use.
Warnings & Precautions
- !Prescription required—FDA-approved only for HIV lipodystrophy.
- !Contraindicated with active malignancy or pituitary pathology.
- !May impair glucose tolerance; monitor fasting glucose and HbA1c.
- !Hypersensitivity reactions possible; discontinue if allergic signs appear.
Frequently Asked Questions
How does tesamorelin differ from Ipamorelin?
Tesamorelin is a GHRH analog (like CJC-1295) while Ipamorelin is a ghrelin mimetic. Tesamorelin is FDA-approved with clinical trial data; Ipamorelin is a research peptide. They work through different receptor pathways.
Can tesamorelin be used off-label for anti-aging?
Some physicians prescribe tesamorelin off-label for age-related GH decline. It produces physiological GH pulsatility, potentially offering advantages over direct GH injections. However, this use is not FDA-approved.
Does tesamorelin cause side effects?
Common side effects include injection site reactions, joint pain, peripheral edema, and myalgia. Glucose metabolism changes require monitoring. Most side effects are related to GH elevation.